Clinical evidences

Total Knee Arthroplasty (TKA)

I-ONE® TPC improves pain control, reduces intra-articular swelling and shortens functional recovery time in patients undergoing total knee arthroplasty. The results are evident two months after TKA.

info.png Treatment protocol: 4 hours per day for 60 days.



Three years after TKA, only 7% of patients treated with I-ONE® TPC complained off knee pain compared to 33% of patients in the control group (who had not used I-ONE® TPC).

I-ONE® TPC should be considered as an effective completion of the surgical procedure.



Anterior Cruciate Ligament (ACL) Reconstruction and Meniscectomy

I-ONE® TPC significantly reduces the consumption of Non Steroidal Anti Inflammatory Drugs (NSAIDs) and shortens the functional recovery time.

info.png Treatment protocol: 4 hours per day for 60 days.




Patients who used I-ONE® TPC for two months following surgery, recovered full joint functionality in one third of the time compared to those not treated with I-ONE® TPC.



Cartilage repair surgery

I-ONE® TPC used soon after microfractures restrains the joint inflammatory process, controls pain (reducing the use of NSAIDs) and improves functional recovery time thus increasing the chances of a successful surgery.

info.png Treatment protocol: 4 hours per day for 60 days.



Similar results are obtained after matrix autologous chondrocyte implantation and after the modern tissue engineering techniques using mesenchymal stem cells.

The effectiveness of I-ONE® TPC is maintained over time, up to 3 years post surgery.



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