A recent work from Dr. Hung et al. from Columbia University in collaboration with IGEA has been published in the peer-reviewed journal “Biotechnology and Bioengineering”.
in this study, the effect of Biophysical Stimulation (I-ONE® therapy) on the structural and functional quality of tissue-engineered cartilage grafts and on post-implant articular environment was assessed.
I-ONE® therapy represents a non-invasive clinical treatment to improve pre-implantation cartilage properties and decrease catabolic activities of pro-inflammatory cytokines post-implantation, leading to good and stable long-term clinical outcomes.
The results show that, in vitro, I-ONE® therapy increases cellular content, extracellular matrix deposition and integration of the engineered constructs.
In focal osteochondral lesions treated with tissue-engineered cartilage grafts, PEMF stimulation promotes the formation of a uniform hyaline-like repair tissue and reduces the levels of pro-inflammatory cytokines.
Altogether, the results demonstrate the ability of I-ONE® therapy to enhance cartilage repair, through the modulation of the graft integration and the control of the joint environment.
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